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Effects of exercise therapy on bone mineral density in early postmenopausal women: a controlled trial

Shilin DENG MD ,

《医学前沿（英文）》 2009年第3卷第3期页码 323-329 doi: 10.1007/s11684-009-0061-2

摘要： The purpose of this article is to determine the effect of a well-designed combined aerobic, resistance, and extension exercise program on bone mineral density (BMD) in postmenopausal women. The population comprised 45 postmenopausal women, who exercised over 12months (exercise group), and 36 women who served as a non-training control group. BMD of the hip, and lumbar spine was measured at the baseline and 12th month. Repeated measurement analysis of variance and nonparametric test were utilized to compare differences between the exercise group and controls. Thirty-six out of 45 persons in the exercise group and 36 controls completed the study. Average compliance was 82.2% for the whole exercise group at the 12th month. All the subjects had decreased BMD, but the rate of bone loss was lower in the exercise group than in the control group at the L4 and hip. Although the exercise program in this study may probably reduce the rate of bone loss in weight-bearing skeletal sites, we do not suggest the exercise by itself be viewed as prevention or treatment for osteoporosis. Further, the exact dose-response relationship of exercise and bone mass in early postmenopause is not clear.

关键词： early postmenopausal women bone mineral density exercise effects

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农村绝经后妇女性生活满意度及其影响因素分析

景秀,杨继高,刘俊,张丽华

《中国工程科学》 2014年第16卷第5期页码 105-109

摘要：

为了探索影响农村绝经后妇女性生活满意度的因素，从而为开展老年妇女保健提供科学依据，笔者于2012 年3—8 月采用多阶段随机抽样方法对重庆市5 个区县农村绝经后妇女采用统一方法进行问卷调查和体检。结果显示，重庆市农村绝经后妇女对目前性生活满意和不满意的分别占83.7 %和16.3 %。单因素分析显示，绝经后妇女性生活满意度与其婚姻状况、文化程度、家庭收入、家庭结构、是否患有妇科疾病、最近两周是否有生殖道不适、起居方式、是否需要性生活、性生活频率、老年性保健知识、自觉体力状态及自觉生活状态等12 个变量有关（P<0.05）；多因素Logistic 回归分析显示，分居方式（比值比（OR）=1.711，95 %置信区间（CI）为1.334～2.194）、性生活频率高（OR=1.694，95 % CI 为1.334～2.152）、自觉体力状态差（OR=1.281，95 % CI 为1.018～1.613）是危险因素，家庭收入高（OR=0.651，95 % CI 为0.512～0.826）和既往有妇科疾病（OR=0.689，95 % CI 为0.486～0.977）是保护因素。因此，农村存在多种影响绝经后妇女性生活满意度的相关因素，应重视对绝经后妇女的性教育，改善她们的生活质量。

关键词：绝经后妇女性生活满意度影响因素 Logistic分析

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How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

《医学前沿（英文）》 2010年第4卷第3期页码 290-293 doi: 10.1007/s11684-010-0093-7

摘要： The relevance of postmenopausal hormone therapy (HT) for breast cancer risk has been long debated, although it is one of the most important barriers for women to accept HT. Various opinions have been reported from recent randomized clinical trials and epidemiological studies. These unanswered questions include: whether HT has a positive impact on breast cancer; whether risks of therapy with unopposed estrogen and combined estrogen-progestin are different; and whether different types and routes of estrogen and progestogens, as well as the duration and cessation of HT use, have different impacts on this disorder. Recently, there has been some good news such as the following: the currently available data do not provide sufficient evidence to prove a causal relationship between postmenopausal HT and breast cancer; breast cancer in postmenopausal women using HT usually has better prognosis than that of nonusers. In conclusion, HT is still the most effective method of relieving climacteric symptoms for many postmenopausal women. However, a possible risk of breast cancer associated with long-term HT usage should not be ignored. With respect to prevention of breast cancer, regular evaluation of individual breast cancer susceptibility and close follow-up through mammography and/or breast sonography are necessary strategies for the safety of HT use.

关键词： breast cancer postmenopausal hormone therapy unopposed estrogen therapy combined estrogen-progestin therapy

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A survey of physical activity among urban women in China

Shilin DENG MD, Tongyuan LIU,

《医学前沿（英文）》 2009年第3卷第4期页码 463-469 doi: 10.1007/s11684-009-0081-y

摘要： Few studies have been conducted to assess the level of physical activity (PA) of women in China. The purpose of this study was to describe the prevalence of PA among women in Wuhan and explore sociodemographic and behavioral correlation to PA for the population. A total of 1359 community-dwelling women (42.9713.60 years old) participated in this study. The long-version IPAQ was used to define the level of PA. 45.7% of women were considered physically active, and 27.5% were vigorously active. The proportion of physical inactivity was around 26.8%. The total and 4 domains of PA showed significant age, education level, and occupation variation. PA tended to be lower as the age declined. PA in transportation, housework, leisure time, and the total tended to be the lowest or the second lowest among the women aged 18–35 years old. PA tended to be lower as the level of education increased. Among the 5 indices, PAwas the lowest among women with college education, especially those with postgraduate education. PA tended to be the lowest among the women of office staff and instructor or technician. Generally, the total and 4 domains of PA showed significant age, education level, and occupation variation. Physical inactivity appears to be more common among younger women, or college-educated women, office ladies, and female instructor and technicians.

关键词： physical activity urban women China

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Effects and mechanisms of acupuncture on women related health

《医学前沿（英文）》 doi: 10.1007/s11684-023-1051-5

摘要： Globally, public health interventions have resulted in a 30-year increase in women’s life expectancy. However, women’s health has not increased when socioeconomic status is ignored. Women’s health has become a major public health concern, for those women from developing countries are still struggling with infectious and labor-related diseases, and their counterparts in developed countries are suffering from physical and psychological disorders. In recent years, complementary and alternative medicine has attracted wide attentions with regards to maintaining women’s health. Acupuncture, a crucial component of traditional Chinese medicine, has been used to treat many obstetric and gynecological diseases for thousands of years due to its analgesic and anti-inflammatory effects and its effects on stimulating the sympathetic/parasympathetic nervous system. To fully understand the mechanism through which acupuncture exerts its effects in these diseases would significantly extend the list of available interventions and would allow for more reasonable advice to be given to general practitioners. Therefore, by searching PubMed and CNKI regarding the use of acupuncture in treating obstetric and gynecological diseases, we aimed to summarize the proven evidence of using acupuncture in maintaining women’s health by considering both its effectiveness and the underlying mechanisms behind its effects.

关键词： acupuncture women health clinical efficacy mechanism

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Untargeted metabolomic analysis of pregnant women exposure to perfluorooctanoic acid at different degrees

《环境科学与工程前沿（英文）》 2023年第17卷第3期 doi: 10.1007/s11783-023-1628-x

摘要：

● Metabolome can distinguish pregnant women exposure to PFOA at different degrees.

关键词： Perfluorooctanoic acid Exposure Pregnant women Metabolomic GSH Microbiota metabolism

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HIV感染孕产妇婚育状况分析

沙吾力·艾力卡,王晓军,艾比拜·买买提明

《中国工程科学》 2014年第16卷第5期页码 60-62

摘要：

本文旨在了解新疆人体免疫缺陷病毒（HIV）感染孕产妇的婚育状况，从而为在感染孕产妇中开展生殖健康教育提供依据，笔者利用2010—2012 年间在预防艾滋病母婴传播管理信息网络直报系统中报告的HIV感染孕产妇个案卡资料进行分析。结果显示：1 692 例感染孕产妇平均年龄为29.03 岁，其中20～29岁的小年龄组孕产妇占53.31 %；传播途径为性传播的占60.52 %；婚姻状况初婚者占多数，但再婚者占一定比例（36.40 %）；两次及以上妊娠者占70.69 %，最多达10 次，但有两次及以上分娩经历者占19.92 %。由此可以看出，新疆HIV感染孕产妇中再婚比例明显高于全国其他省（自治区），终止妊娠者占一定比例，因此在女性感染者中有针对性地开展生殖健康教育活动势在必行。

关键词： HIV感染孕产妇女性感染者婚内传播生殖健康

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RESEARCH AND APPLICATION OF CROP PEST MONITORING AND EARLY WARNING TECHNOLOGY IN CHINA

《农业科学与工程前沿（英文）》 2022年第9卷第1期页码 19-36 doi: 10.15302/J-FASE-2021411

摘要：

The importance of food security, especially in combating the problem of acute hunger, has been underscored as a key component of sustainable development. Considering the major challenge of rapidly increasing demands for both food security and safety, the management and control of major pests is urged to secure supplies of major agricultural products. However, owing to global climate change, biological invasion (e.g., fall armyworm), decreasing agricultural biodiversity, and other factors, a wide range of crop pest outbreaks are becoming more frequent and serious, making China, one of the world’s largest country in terms of agricultural production, one of the primary victims of crop yield loss and the largest pesticide consumer in the world. Nevertheless, the use of science and technology in monitoring and early warning of major crop pests provides better pest management and acts as a fundamental part of an integrated plant protection strategy to achieve the goal of sustainable development of agriculture. This review summarizes the most fundamental information on pest monitoring and early warning in China by documenting the developmental history of research and application, Chinese laws and regulations related to plant protection, and the National Monitoring and Early Warning System, with the purpose of presenting the Chinese model as an example of how to promote regional management of crop pests, especially of cross border pests such as fall armyworm and locust, by international cooperation across pest-related countries.

关键词： China / law / early warning system and national crop pest monitoring / pest management / regulation and sustainable agricultural development

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Expression of inducible nitric oxide synthase in trophoblasts and deciduas in early medical abortion

Geqing XIA, Chaoying WU

《医学前沿（英文）》 2009年第3卷第2期页码 216-219 doi: 10.1007/s11684-009-0028-3

摘要： The purpose of this study was to investigate the expression of inducible nitric oxide synthase in trophoblasts and deciduas in early medical abortion, and study the relationship of medical abortion through mifepristone and inducible nitric oxide synthase (iNOS) in early pregnancy. Expression of iNOS in trophoblasts and deciduas was detected by both hybridization and immunohistochemical assay in 40 patients (experimental group); the positive expression of iNOS was represented by number density (N/S) and positive unit (Pu) using computer color magic image analysis system (CMIAS). All results were compared with that obtained from vacuum aspiration. In the experimental group, N/S and Pu in trophoblasts were 0.120 ± 0.010 and 15.3 ± 2.6, respectively, while in the control group, they were 0.021 ± 0.003 and 3.1 ± 0.5, respectively, and there were significant differences between the two groups. By immunohistochemical assay, N/S and Pu were 0.090 ± 0.010, 10.24 ± 1.55 0.016 ± 0.002, 1.26 ± 0.33 in the trophoblasts of the two groups; there were also significant differences between the two groups. There were lower iNOS expressions in deciduas by in situ hybridization and immunohistochemical assay, and the difference between the two groups was not significant.It was concluded that mifepristone induced medical abortion through the expression of iNOS in trophoblasts but not in deciduas.

关键词： mifepristone inducible nitric oxide synthase early pregnancy placental immunity

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Epidemiological studies of women under age 30 infected with human papillomavirus

Zhihua LIU MD, Qing LI BM, Weihong LI BM,

《医学前沿（英文）》 2009年第3卷第4期页码 459-462 doi: 10.1007/s11684-009-0084-8

摘要： The aim of this paper was to investigate the prevalence of human papilloma virus (HPV) infection in women under 30 years old with cervical intraepithelial neoplasia (CIN) or cervical cancer, in order to provide a basis for cervical cancer prevention and treatment. We recruited 2052 female cases from the education system in Futian District, Shenzhen city, from April 2006 to April 2008, with age ranging from 22 to 60 years old. Second-generation hybrid capture test was done for detection of female genital tract HPV and cervical colposcopy for screening CIN or cervical cancer. The prevalence of HPV and cervical precancerous lesions or cervical cancer was evaluated in different age groups of women. The HPV positive rate was 247/2052 (12.00%), and 35/2052 (1.71%) of the cases were≥CIN I by pathological diagnosis. In the 22―29-year-old age group, there were 291 cases, including 39HPV-positive cases (13.40%) and one case of pathological diagnosis≥CIN I (0.34%), and there were 1761 cases in the 30―60-year-old age group, including 208 HPV-positive cases (11.81%) and 34 cases of pathological diagnosis≥CIN I (1.93%). The HPV-positive rate of 22―29-year-old age group was higher than that of 30―60-year-old age group, but the difference was not significant ( = 0.5967, = 0.4398); the CIN and cervical cancer detection rate of the former group was lower than that of the latter one, and the difference was not significant either ( = 3.7519, = 0.0527). The cases in 30―60-year-old age group were divided into five age sub-groups, and the HPV-positive rate of the 22―29-year-old age group was compared with the remaining groups, and it was found that the HPV-positive rate of the former group (13.40%) was lower than that of the 40―44-year-old age group (14.70%) but higher than that of the other four groups. Moreover, the difference in the HPV-positive rate between the 22―29-year-old age group and the 50―60-year-old age group (6.06%) was significant ( = 5.545, = 0.018), but the difference between the 22― 29-year-old age group and each of the other four groups was not significant (>0.05). In addition, the CIN and cervical cancer detection rate of the 22―29-year-old age group (0.34%) was lower than that of the remaining five groups, and the difference between the 22―29-year-old age group and the 35―39-year-old age group (2.26%), and between 22―29-year-old age group and 40―44-year-old age group (2.30%) was significant ( = 4.446, = 0.0035; = 4.525, = 0.0363, respectively), but the difference between the 22―29-year-old age group and each of other three groups was not significant (>0.05). Furthermore, 80.00% (28/35) cases of pathological diagnosis≥CIN I and 90.91% (10/11) lesions of pathological diagnosis≥CIN II occurred at 35―49 years of age. For many young women below the age of 30 who were infected with high-risk HPV were one-off infections, so it was not appropriate to recommend HPV detection as cervical precancerous lesions or cancer screening program for women less than 30 years old. The prevention and treatment of cervical cancer should be focused on those women more than 35 years of age.

关键词： cervical cancer human papilloma virus cervical intraepithelial neoplasia

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Role of chemerin/CMKLR1 in the maintenance of early pregnancy

Xuezhou Yang, Junning Yao, Qipeng Wei, Jinhai Ye, Xiaofang Yin, Xiaozhen Quan, Yanli Lan, Hui Xing

《医学前沿（英文）》 2018年第12卷第5期页码 525-532 doi: 10.1007/s11684-017-0577-9

摘要：

Chemerin is a cytokine that attracts much attention in the reproductive process. This study aimed to explore the effects of chemerin and its receptor chemokine-like receptor 1 (CMKLR1) on the maintenance of early pregnancy. The expression levels of chemerin and CMKLR1 in the decidua tissues of 20 early normal pregnant women and 20 early spontaneous abortion women were examined by Western blot and real-time polymerase chain reaction analyses. CMKLR1 receptor antagonist (α-NETA) was then intrauterinely injected into normal pregnant mice model to assess its effect on the outcome of pregnancy and the phosphorylation rate of ERK1/2 in decidua tissues. We found that the expression level of chemerin in women who had experienced early spontaneous abortion was lower than in those who had experienced normal early pregnancy (P<0.01); conversely, CMKLR1 expression was higher in the former than in the latter (P<0.01). In a pregnant-mouse model, the embryo resorption rate of α-NETA group was higher than that in the negative control group (61.5% vs. 10.8%) (P<0.001). Compared with the control group, ERK1/2 phosphorylation in decidua tissues decreased in the α-NETA-treated group (P<0.01). These results suggested that the inhibition of the chemerin/CMKLR1 signaling pathway can lead to the abortion of mouse embryos, and that chemerin/CMKLR1 may play an important role in the maintenance of early pregnancy possibly by regulating ERK1/2 phosphorylation.

关键词： chemerin CMKLR1 early abortion

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Weak characteristic information extraction from early fault of wind turbine generator gearbox

Xiaoli XU, Xiuli LIU

《机械工程前沿（英文）》 2017年第12卷第3期页码 357-366 doi: 10.1007/s11465-017-0423-4

摘要：

Given the weak early degradation characteristic information during early fault evolution in gearbox of wind turbine generator, traditional singular value decomposition (SVD)-based denoising may result in loss of useful information. A weak characteristic information extraction based on µ-SVD and local mean decomposition (LMD) is developed to address this problem. The basic principle of the method is as follows: Determine the denoising order based on cumulative contribution rate, perform signal reconstruction, extract and subject the noisy part of signal to LMD and µ-SVD denoising, and obtain denoised signal through superposition. Experimental results show that this method can significantly weaken signal noise, effectively extract the weak characteristic information of early fault, and facilitate the early fault warning and dynamic predictive maintenance.

关键词： wind turbine generator gearbox µ-singular value decomposition local mean decomposition weak characteristic information extraction early fault warning

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Early-onset diabetes: an epidemic in China

Jiemin Pan, Weiping Jia

《医学前沿（英文）》 2018年第12卷第6期页码 624-633 doi: 10.1007/s11684-018-0669-1

摘要：

Although type 2 diabetes is a disease often associated with aging, the global prevalence of early-onset diabetes has been increasing due to man’s sedentary lifestyle, low-physical activity, obesity, and some non-modifiable risk factors. Many studies have found that individuals with early-onset type 2 diabetes were at higher risk of developing vascular complications than those with late-onset diabetes. Individuals with early-onset diabetes are usually unwilling to visit hospital and have more confidence in their health, which results in poor glycemic control and the delayed detection of diabetes-related complications. Few studies have focused on the treatment and prevention of complications in specific population of individuals with early-onset type 2 diabetes. Therefore, focusing on this particular population is critical for the government and academic societies. Screening for T2DM is imminent for young adults with a family history of diabetes, obesity, markers of insulin resistance, or alcohol consumption. More data are definitely required to establish a reasonable risk model to screen for early-onset diabetes.

关键词： diabetes early-onset diabetes complications

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Biosensor-based assay of exosome biomarker for early diagnosis of cancer

《医学前沿（英文）》 2022年第16卷第2期页码 157-175 doi: 10.1007/s11684-021-0884-z

摘要： Cancer imposes a severe threat to people’s health and lives, thus pressing a huge medical and economic burden on individuals and communities. Therefore, early diagnosis of cancer is indispensable in the timely prevention and effective treatment for patients. Exosome has recently become an attractive cancer biomarker in noninvasive early diagnosis because of the unique physiology and pathology functions, which reflects remarkable information regarding the cancer microenvironment, and plays an important role in the occurrence and evolution of cancer. Meanwhile, biosensors have gained great attention for the detection of exosomes due to their superior properties, such as convenient operation, real-time readout, high sensitivity, and remarkable specificity, suggesting promising biomedical applications in the early diagnosis of cancer. In this review, the latest advances of biosensors regarding the assay of exosomes were summarized, and the superiorities of exosomes as markers for the early diagnosis of cancer were evaluated. Moreover, the recent challenges and further opportunities of developing effective biosensors for the early diagnosis of cancer were discussed.

关键词： biosensor exosome cancer diagnosis

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天津滨海新区产后妇女对避孕相关问题的认知现状分析

秦丽艳

《中国工程科学》 2015年第17卷第6期页码 53-56

摘要：

通过对天津滨海新区产后妇女对避孕相关问题的认知现状的调查分析，以期认识到提高产后妇女的整体避孕意识的必要性。采用自行设计问卷，由固定医师进行询问并填写问卷。产后妇女中81.9 %的人知道产后应该避孕，但只有46.9 %知道产后高危人工流产的危害，48.8 %的产后妇女没有避孕计划或打算3个月后再采取避孕措施，47.2 %的产后妇女计划或已于首次性生活采取避孕措施，其中学历高、职业为干部组、剖宫产的产后妇女避孕意识较好，258人（80.6 %）通过住院分娩或产后访视得知产后应避孕，207人（64.7 %）在产后避孕方法上首选避孕套。产后妇女选择长效可靠避孕措施的少，医护工作者应提高对产后妇女有关产后避孕的指导和宣传，提高产后妇女对避孕效果可靠措施的使用率，提高产后妇女的生活质量。

关键词：产后妇女；避孕；人工流产

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标题作者时间类型操作

Effects of exercise therapy on bone mineral density in early postmenopausal women: a controlled trial

Shilin DENG MD ,

期刊论文

农村绝经后妇女性生活满意度及其影响因素分析

景秀,杨继高,刘俊,张丽华

期刊论文

How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

期刊论文